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KMID : 0311120110520010196
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Yonsei Medical Journal
2011 Volume.52 No. 1 p.196 ~ p.198
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Complete Atrioventricular Block Secondary to Bortezomib Use in Multiple Myeloma
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Lee Won-Seop
Kim Dae-Hyeok
Shin Sung-Hee
Woo Seoung-Il
Kwan Jun
Park Keum-Soo
Park Sang-Don
Yi Hyeon-Gyu
Jeon Sang-Hoon
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Abstract
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Bortezomib is an inhibitor of 26S proteasome, which is an effective treatment for multiple myeloma. The common adverse effects of bortezomib are asthenic conditions, gastrointestinal disturbances, and peripheral neuropathy. Here we describe a patient with dyspnea and general weakness because of complete atrioventricular block while receiving bortezomib. We immediately stopped bortezomib, and after inserting a permanent VDD pacemaker, the patients’ symptoms disappeared.
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KEYWORD
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Bortezomib, multiple myeloma, adverse effect, atrioventricular block
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