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KMID : 0311120110520030543
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Yonsei Medical Journal
2011 Volume.52 No. 3 p.543 ~ p.546
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Effect of Zoledronic Acid on Acro-Osteolysis and Osteoporosis in a Patient with Hajdu-Cheney Syndrome
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Hwang Se-Na
Shin Dong-Yoeb
Moon Seong-Hwan
Lee Eun-Jig
Lim Sung-Kil
Kim Ok-Hwa
Rhee Yu-Mie
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Abstract
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Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself.
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KEYWORD
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Hajdu-Cheney Syndrome, osteoporosis, zoledronic acid
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