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KMID : 0311120110520040588
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Yonsei Medical Journal
2011 Volume.52 No. 4 p.588 ~ p.594
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Anti-Proteinuric Effect of Sulodexide in Immunoglobulin A Nephropathy
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Bang Ki-Tae
Chin Ho-Jun
Chae Dong-Wan
Joo Kwon-Wook
Kim Yon-Su
Kim Suhng-Gwon
Ju Kyung-Don
Kim Hwa-Jung
Ahn Curie
Oh Kook-Hwan
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Abstract
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Purpose: We conducted a multi-center randomized double-blind study to determine the effects of 6-month therapy with sulodexide on urinary protein excretion in patients with idiopathic Immunoglobulin A (IgA) nephropathy.
Materials and Methods: A total of seventy-seven patients participated in the study. They were randomly allocated to one of three groups: sulodexide 75 mg or 150 mg daily or the placebo for 6 months. The primary end point was the achievement, at 6 months, of at least 50% reduction in urine protein/creatinine ratio (UPCR) from the baseline value.
Results: At 6 months, the primary end point was achieved by 12.5% of the patients assigned to the placebo, 4.0% of the patients assigned to sulodexide 75 mg daily and 21.4% of those assigned to 150 mg (p=0.308). Treatment with sulodexide 150 mg daily for 6 months significantly reduced log UPCR from 6.38±0.77 at baseline to 5.98±0.94 at 6 months (p=0.045), while treatment with sulodexide 75 mg daily and placebo did not.
Conclusion: A 6-month treatment with sulodexide did not achieve 50% reduction of urinary protein excretion in IgA nephropathy patients, but showed a tendency to increase the time-dependent anti-proteinuric effect. Therefore, long-term clinical trials on a larger scale are warranted to elucidate the hypothesis that sulodexide affords renal protection in IgA nephropathy patients.
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KEYWORD
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IgA nephropathy, sulodexide, proteinuria
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