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KMID : 0311120110520060953
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Yonsei Medical Journal
2011 Volume.52 No. 6 p.953 ~ p.960
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The Association of SERPINE2 Gene with COPD in a Chinese Han Population
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Wang Aihua
Yu Qinfeng
Xiao Wei
Yin Yingqiu
Chen Ping
Liu Qiji
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Abstract
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Purpose: Polymorphisms of several candidate genes have been studied and associated with the development of chronic obstructive pulmonary disease (COPD). One such candidate is the SERPINE2 (Serpin peptidase inhibitor, clade E member 2) gene.
Materials and Methods : To assess whether the SERPINE2 gene is associated with COPD in a Chinese Han population. Samples were collected from a Chinese Han population and analyzed for the association of single nucleotide polymor phisms (SNPs) or haplotypes of SERPINE2 gene with COPD in a case-control study. Three SNPs including rs840088 G/A in intron 1, rs1438831 A/G in 5’ upstream sequence and rs3795879 G/A in intron 3 were detected using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism technique in 409 COPD subjects and 411 controls. Genotyping of the SREPINE2 polymorphisms at positions rs840088, rs1438831and rs3795879 was performed.
Results: We found that none of the rs840088G/A, rs1438831G/A and rs3795879 G/A polymorphisms were associated with the disease. The p-values were 0.630, 0.208 and 0.398 respectively.
Conclusion: Our data suggested that there was no significant association between SERPINE2 polymorphism and COPD susceptibility in the Chinese Han population.
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KEYWORD
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Chronic obstructive pulmonary disease, SERPINE2 gene, polymorphism, susceptibility
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