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KMID : 0311120160570041034
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Yonsei Medical Journal
2016 Volume.57 No. 4 p.1034 ~ p.1037
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In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
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Lee Sun-Myoung
Kwon Hae-Yoon
Im Jae-Hyoung
Baek Ji-Hyeon
Hwang Seung-Sik
Kang Jae-Seung
Chung Moon-Hyun
Lee Jin-Soo
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Abstract
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Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10-3 μg/mL in doxycycline-treated group. Whereas in 0.71×10-3 μg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus.
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KEYWORD
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Orientia tsutsugamushi, scrub typhus, tigecycline, IC50
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