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KMID : 0311120160570061339
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Yonsei Medical Journal
2016 Volume.57 No. 6 p.1339 ~ p.1346
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Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction
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Bang Woo-Dae
Kim Ki-woong
Lee Yong-Ho
Kwon Hyuk-chan
Park Yong-ki
Pak Hui-Nam
Ko Young-Guk
Lee Moon-Hyoung
Joung Bo-Young
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Abstract
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Purpose: Magnetocardiography (MCG) has been proposed as a noninvasive, diagnostic tool for risk-stratifying patients with acute myocardial infarction (AMI). This study evaluated whether MCG predicts long-term prognosis in AMI.
Materials and Methods: In 124 AMI patients (95 males, mean age 60±11 years), including 39 with ST-elevation myocardial infarction, a 64-channel MCG was performed within 2 days after AMI. During a mean follow-up period of 6.1 years, major adverse cardiac events (MACE) were evaluated.
Results: MACE occurred in 31 (25%) patients, including 20 revascularizations, 8 deaths, and 3 re-infarctions. Non-dipole patterns were observed at the end of the T wave in every patients. However, they were observed at T-peak in 77% (24/31) and 54% (50/93) of patients with and without MACE, respectively (p=0.03). Maximum current, field map angles, and distance dynamics were not different between groups. In the multivariate analysis, patients with non-dipole patterns at T-peak had increased age- and gender-adjusted hazard ratios for MACE (hazard ratio 2.89, 95% confidence interval 1.20?6.97, p=0.02) and lower cumulative MACE-free survival than those with dipole patterns (p=0.02).
Conclusion: Non-dipole patterns at T-peak were more frequently observed in patients with MACE and were related to poor long-term prognosis. Thus, repolarization heterogeneity measured by MCG may be a useful predictor for AMI prognosis.
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KEYWORD
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Acute myocardial infarction, prognosis, magnetocardiography
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