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KMID : 0311120170580061152
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Yonsei Medical Journal
2017 Volume.58 No. 6 p.1152 ~ p.1159
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A Gender-Specific Association between Self-Reported Snoring and Hemoglobin A1c Levels in a General Population without Type 2 Diabetes Mellitus
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Lee Young-Hoon
Kweon Sun-Seog
Choi Jin-Su
Nam Hae-Sung
Park Kyeong-Soo
Choi Seong-Woo
Oh Su-Hyun
Kim Sun-A
Shin Min-Ho
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Abstract
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Purpose: We explored whether a gender difference was evident in terms of the associations of snoring with hemoglobin A1c (HbA1c) and homeostatic model assessment-insulin resistance (HOMA-IR) levels in a healthy population without type 2 diabetes mellitus (DM).
Materials and Methods: We analyzed 2706 males and 4080 females who participated in the baseline survey of the Namwon Study. In terms of self-reported snoring frequency, participants were classified as non-snorers or occasional (1?3 days/week), frequent (4?6 days/week), or constant (7 days/week) snorers. Participants with DM, defined as a fasting blood glucose level ≥126 mg/dL and/or use of insulin or hypoglycemic medication, were excluded from the analysis.
Results: In females, the fully adjusted mean (95% confidence interval) HbA1c levels in non-snorers and in occasional, frequent, and constant snorers were 5.53% (5.47?5.59%), 5.53% (5.47?5.59%), 5.57% (5.49?5.64%), and 5.57% (5.51?5.64%), respectively, reflecting a dose-response relationship (p trend=0.004). Compared with female non-snorers, the risk of an elevated HbA1c level (top quintile, ≥5.9%) in constant snorers remained significant (odds ratio 1.30, 95% confidence interval 1.02?1.66) after full adjustment. In addition, in females, a significant linear trend in HbA1c level odds ratio by increased snoring frequency was apparent (p trend=0.019 in model 3). In contrast, no significant association between snoring frequency and HbA1c level was identified in males. No significant association between snoring frequency and HOMA-IR was detected in either gender.
Conclusion: We discovered a gender-specific association between snoring and HbA1c level in a healthy, community-dwelling population free of DM.
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KEYWORD
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Snoring, hemoglobin A, glycosylated, insulin resistance, gender
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