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KMID : 0311120190600060535
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Yonsei Medical Journal
2019 Volume.60 No. 6 p.535 ~ p.541
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Effect of Cardiac Rehabilitation on Outcomes in Patients with ST-Elevation Myocardial Infarction
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Lee Hye-Young
Hong Sung-Jin
Jung In-Hyun
Kim Gwang-Sil
Byun Young-Sup
Kim Byung-Ok
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Abstract
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Purpose: Whether cardiac rehabilitation (CR) improves clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) has not been thoroughly evaluated. Moreover, few studies have sought to identify patients who would benefit most from CR among STEMI patients.
Materials and Methods: Consecutively, 265 STEMI patients who underwent primary PCI with implantation of DESs and follow-up angiography were examined. Seventy-six patients (30%) who received CR were assigned to the CR+ group. Another 178 patients (70%) who did not participate in CR were assigned to the CR? group. Second generation DESs were implanted in 238 (94%) patients.
Results: Major adverse cardiovascular events (MACEs), including death, myocardial infarction, and revascularization, were compared. The CR+ group tended to have lower MACE than the CR? group at 3 years, although the difference was not statistically significant (9.9% vs. 18.3%, hazard ratio=0.54, p=0.138). Subgroup analysis revealed a significant interaction according to CR and preprocedural thrombolysis in myocardial infarction (TIMI) flow (p value for interaction=0.011). In patients with low preprocedural TIMI flow (TIMI flow ≤1, n=161), those in the CR+ group had significantly lower MACE than those in the CR? group (p=0.005), whereas MACE was not different among patients with higher TIMI flow (TIMI flow ≥2, n=93).
Conclusion: CR including exercise training was associated with lower MACE, particularly in patients with lower preprocedural TIMI flow during primary PCI for STEMI in the current DES era.
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KEYWORD
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Cardiac rehabilitation, myocardial infarction, drug eluting stent
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