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KMID : 0311120190600100960
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Yonsei Medical Journal
2019 Volume.60 No. 10 p.960 ~ p.968
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Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome
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Kim Min-Ji
Ahn Young-Min
Yoo Young
Kim Dong-Kyu
Yang Hyeon-Jong
Park Hae-Sim
Lee Hyun-Jong
Kim Mi-Ae
Jeong Yi-Yeong
Kim Bong-Seong
Bae Woo-Yong
Jang An-Soo
Park Yang
Koh Young-Il
Lee Jae-Chun
Lim Dae-Hyun
Kim Jeong-Hee
Lee Sang-Min
Kim Yong-Min
Jun Young-Joon
Kim Hyo-Yeol
Kim Yun-Sun
Choi Jeong-Hee
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Abstract
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Purpose: Many studies have reported that pollen-food allergy syndrome (PFAS) can cause anaphylaxis. No comprehensive investigations into anaphylaxis in PFAS have been conducted, however. In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis.
Materials and Methods: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130).
Results: The most common cause of anaphylaxis in PFAS was peanut (33.3%), apple (22.2%), walnut (22.2%), pine nut (18.5%), peach (14.8%), and ginseng (14.8%). Anaphylaxis was significantly associated with the strength of sensitization to alder, hazel, willow, poplar, timothy, and ragweed (p<0.05, respectively). Multivariable analysis revealed that the presence of atopic dermatitis [odds ratio (OR), 3.58; 95% confidence interval (CI), 1.25?10.23; p=0.017]; sensitization to hazel (OR, 5.27; 95% CI, 1.79?15.53; p=0.003), timothy (OR, 11.8; 95% CI, 2.70?51.64; p=0.001), or ragweed (OR, 3.18; 95% CI, 1.03?9.87; p=0.045); and the number of culprit foods (OR, 1.25; 95% CI, 1.15?1.37; p<0.001) were related to the development of anaphylaxis in PFAS.
Conclusion: The most common culprit foods causing anaphylaxis in PFAS were peanut and apple. The presence of atopic dermatitis; sensitization to hazel, timothy, or ragweed; and a greater number of culprit foods were risk factors for anaphylaxis in PFAS.
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KEYWORD
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Pollen-food allergy syndrome, pollen, food allergy, anaphylaxis
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