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KMID : 0311120190600100992
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Yonsei Medical Journal
2019 Volume.60 No. 10 p.992 ~ p.997
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Characteristics of Lung Allocation and Outcomes of Lung Transplant according to the Korean Urgency Status
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Yu Woo-Sik
Kim Song-Yee
Kim Young-Tae
Lee Hyun-Joo
Park Samina
Choi Sun-Mi
Kim Do-Hyung
Cho Woo-Hyun
Yeo Hye-Ju
Park Seung-Il
Choi Se-Hoon
Hong Sang-Bum
Shim Tae-Sun
Jo Kyung-Wook
Jeon Kyeong-Man
Jeong Byeong-Ho
Paik Hyo-Chae
Lee Jin-Gu
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Abstract
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Purpose: We investigated the characteristics of lung allocation and outcomes of lung transplant (LTx) according to the Korean urgency status.
Materials and Methods: LTx registration in the Korean Organ Transplantation Registry (KOTRY) began in 2015. From 2015 to June 2017, 86 patients who received LTx were enrolled in KOTRY. After excluding one patient who received a heart-lung transplant, 85 were included. Subjects were analyzed according to the Korean urgency status.
Results: Except for Status 0, urgency status was classified based on partial pressure of oxygen in arterial blood gas analysis and functional status in 52 patients (93%). The wait time for lung allograft was well-stratified by urgency (Status 0, 46.5±59.2 days; Status 1, 104.4±98.2 days; Status 2 or 3, 132.2±118.4 days, p=0.009). Status 0 was associated with increased operative times and higher intraoperative blood transfusion. Status 0 was associated with prolonged extracorporeal membrane oxygenation use, postoperative bleeding, and longer mechanical ventilation after operation. Survival of Status 0 patients seemed worse than that of non-Status 0 patients, although differences were not significant.
Conclusion: The Korean urgency classification for LTx is determined by using very limited parameters and may not be a true reflection of urgency. Status 0 patients seem to have poor outcomes compared to the other urgency status patients, despite having the highest priority for donor lungs. Further multi-center and nationwide studies are needed to revise the lung allocation system to reflect true urgency and provide the best benefit of lung transplantation.
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KEYWORD
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Lung transplant, lung allocation, post-transplant survival
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