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KMID : 0311120190600121117
Yonsei Medical Journal
2019 Volume.60 No. 12 p.1117 ~ p.1128
Circular RNAs Regulate Cancer Onset and Progression via Wnt/¥â-Catenin Signaling Pathway
Li Yun-Feng

Zhang Jian
Yu Lei
Abstract
Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore, it is imperative to explore the mechanisms underlying cancer initiation and development, and design novel diagnostics and therapeutics. Circular RNAs (circRNAs), which exhibit a covalently closed loop structure, are involved in a variety of diseases, including cancer. The aberrant expression of circRNAs contributes to the initiation and development of various cancers by disrupting the interplay of specific signaling pathways, including the Wnt/¥â-catenin pathway, which controls a plethora of cellular processes that drive cancer development. The interactions between circRNAs (specifically expressed in different cancer tissues) and Wnt/¥â-catenin signaling pathway presents potential diagnostic biomarkers and novel therapeutic targets. In this review, we have summarized research discoveries on the functions of Wnt/¥â-catenin pathway-related circRNAs in the modulation of oncogenesis and progression of different types of cancer. We anticipate that our findings will contribute to the improvement or development of circRNAs-based strategies for cancer treatment.
KEYWORD
Circular RNA, cancer, Wnt/¥â-catenin signaling pathway
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