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KMID : 0311120200610010100
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Yonsei Medical Journal
2020 Volume.61 No. 1 p.100 ~ p.102
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Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
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Leem Ga-Lam
Kim Beom-Kyung
Shin Eui-Cheol
Park Jun-Yong
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Abstract
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To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
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KEYWORD
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Autoimmune hepatitis, acute hepatitis A, regulatory T cells, inflammatory conversion of Treg cells
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