|
KMID : 0311120200610121004
|
|
Yonsei Medical Journal
2020 Volume.61 No. 12 p.1004 ~ p.1012
|
|
|
Impact of Dissection after Drug-Coated Balloon Treatment of De Novo Coronary Lesions: Angiographic and Clinical Outcomes
|
|
Hui Lin
Shin Eun-Seok
Jun Eun-Jung
Bhak Young-June
Garg Scot
Kim Tae-Hyun
Sohn Chang-Bae
Choi Byung-Joo
Kun Liu
Yuan Song Lin
Zhi Wang
Hao Jiang
Shi Zhentao
Qiang Tang
|
|
|
Abstract
|
|
|
Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with a high risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections and subsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novo coronary lesions.
Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) following DCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vessel failure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vessel thrombosis).
Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differences in LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariate analysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completely healed, and there was no newly developed dissection at 6-month angiography.
Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associated with an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).
|
|
|
KEYWORD
|
|
|
Balloon angioplasty, dissection, coronary heart disease, outcome research
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|