|
KMID : 0311120200610121034
|
|
Yonsei Medical Journal
2020 Volume.61 No. 12 p.1034 ~ p.1041
|
|
|
Characteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study
|
|
Kwak Se-Hyun
Choi Ji-Soo
Lee Eun-Hye
Lee Su-Hwan
Leem Ah-Young
Lee Sang-Hoon
Kim Song-Yee
Chung Kyung-Soo
Kim Eun-Young
Jung Ji-Ye
Park Moo-Suk
Kim Young-Sam
Chang Joon
Kang Young-Ae
|
|
|
Abstract
|
|
|
Purpose: Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associated with unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration for Hr-TB are currently under discussion. We evaluated the characteristics and treatment outcomes of Hr-TB patients.
Materials and Methods: We retrospectively reviewed the medical records of Hr-TB patients treated at a South Korean tertiary referral hospital from January 2005 to December 2018.
Results: We included 195 Hr-TB patients. 113 (57.9%) were male, and the median age was 56.6 [interquartile range, 40.2?68.6] years. Mutations in katG were the most frequent [54 (56.3%)], followed by those in the inhA [34 (35.4%)]. Favorable and unfavorable outcomes were noted in 164 (84.1%) and 31 (15.9%) patients, respectively. Smoking history [odds ratio (OR)=5.606, 95% confidence interval (CI): 1.695?18.543, p=0.005], low albumin level (OR=0.246, 95% CI: 0.104?0.578, p=0.001), and positive acid-fast bacilli culture at 2 months (OR=7.853, 95% CI: 1.246?49.506, p=0.028) were associated with unfavorable outcomes.
Conclusion: A tailored strategy targeting high-risk patients is imperative for improved treatment outcomes. Further research on the rapid and accurate detection of resistance to INH and other companion drugs is warranted.
|
|
|
KEYWORD
|
|
|
Tuberculosis, isoniazid, treatment outcome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|