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KMID : 0311120220630020148
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Yonsei Medical Journal
2022 Volume.63 No. 2 p.148 ~ p.157
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Efficacy and Safety of Anti-Tumor Necrosis Factor-Alpha Agents for Patients with Intestinal Behcet’s Disease: A Systematic Review and Meta-Analysis
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Zhang Qingfeng
Ma Chunyan
Dong Rongrong
Xiang Weizhen
Li Meiqi
Ma Zhenzhen
Yang Qingrui
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Abstract
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Purpose: Intestinal Behcet’s disease (BD) is a systemic autoimmune disease for which treatment options are limited. As a prospective therapeutic strategy for intestinal BD, anti-tumor necrosis factor-alpha (anti-TNF-α) agents have received increasing attention. In this study, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of anti-TNF-α agents for patients with intestinal BD.
Materials and Methods: We searched PubMed, Embase, and Cochrane Library databases up to July 1, 2021 and articles that met the eligibility criteria were further assessed. Pooled rates were synthesized by a randomized effects model using Stata software.
Results: Eleven clinical trials covering 671 patients with intestinal BD were included. According to compositive data, the pooled rate for remission was 39% [95% confidence interval (CI) 26?52] in patients receiving anti-TNF-α agents. Intestinal symptoms were cured in 70% (95% CI 53?84) of the patients, and the rate for endoscopic healing was 65% (95% CI 52?78). Corticosteroid discontinuation was achieved in 43% (95% CI 28?58) of the patients, and the dose reduction of corticosteroid was 20.43 mg (95% CI 13.4?27.46). There were 239 adverse events and 80 serious adverse events during follow-up.
Conclusion: Our study indicated that anti-TNF-α agents may serve as an effective treatment with acceptable safety for patients with intestinal BD. However, more robust evidence from randomized controlled trials is urgently needed to assess the long-term efficacy and safety of anti-TNF-α agents for those patients.
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KEYWORD
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Anti-tumor necrosis factor-alpha, intestinal Behcet’s disease, efficacy, safety, meta-analysis
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