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KMID : 0311219700010010044
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Yonsei Reports on Tropical Medicine
1970 Volume.1 No. 1 p.44 ~ p.50
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Virulence of Entamoeba histolytica According to the Strains in Korea
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Cho, Kee-Mok
Lee, Jun-Young/Soh, Chin-Thack
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Abstract
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The amebicidal activity of traditional antiamoehic drugs (emetine, carbarsone, diodoquin, chloroquine, atabrine, chloramphenicol and tetracycline) and newly appeared chemicals (niridazole, metronidazole and No. 8603 substance) were assayed by in vitro experiment using five strains of human originated E. histolytica. The variety of amebicidal activity of drugs by the strains were discussed.
1. Ranges of arnoebicidal activity of traditional antiamoebic drugs kept almost similar titers of previous reports at the concentrations; 1:5, 000 to 1:20, 000 with emetine hydrochloride, 1:10, 000 to 1 : 20, 000 with carbarsone, 1 : 8, 000 to 1 : 16, 000 with diodoquin, 1 : 50, 000 with chloroquine, 1 : 1, 000 to 1 : 4, 000 with atabrine, 1 : 1, 000 to 1 : 2, 000 with chloramphenicol and 1 : 5, 000 to 1 : 8, 000 with tetracycline. The newly appeared chemicals showed higher amebicidal titres at the concentrations; 1:500, 000 to 1:5, 000, 000 with niridazole, 1 : 50, 000 to 1 : 100, 000 with metronidazole and 1 : 100, 000 to 1:500, 000 with No. 8603 substance.
2. Emetine, chloramphenicol and No. 8603 substance showed amebicidal activities at higher concentration to intestine originated amebae (YS 14, YS15 and NAMRU Ⅱ-strain) than to liver originated amebae (YS24 and YS25-strain), while carbarsone, chloroquine and metroniazole showed the activity at lower concentrations.
Diodoquin showed lower amebicidal titres to trophozoite borne amebae (NAMRU Ⅲ, YS24 and YS25-strain) than to cyst borne amebae(YS 14 and YS15-strain) but, niridazole showed controverse results. The concentraticn of atabrine for amebicidal activity was not constant according to strains of the ´amoeba, but tetracycline showed almost settled titers.
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