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KMID : 0311219740050010117
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Yonsei Reports on Tropical Medicine
1974 Volume.5 No. 1 p.117 ~ p.129
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Quantitative Comparison of the Production, Development and Distribution of Eggs of Schistosoma mansoni in Mice Infected with One-and Multi-Paired Worms
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Fan, Ping-Chin
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Abstract
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The results of infecting albino mice with presexed cercariae of S. mansoni; each with 1-pair worms percutaneously in one group, and each with multi-paired worms intraperitoneally in another group were studied in respect to production of eggs in mature females, and dispersal and developmental stages in various organs.
1) At 822 weeks of infection age, 93% of mature females in 1-pair worms had eggs in utero, average number per female was 1. 3 eggs; and only 83% of 36 of multi-paired worms were positive, with 0.8 egg per female.
2) The average number of eggs in the feces per female per day was 162 in 1-pair worms group. The corresponding number in multi-paired worms group was 267.
3) The viable eggs in liver (57%) and intestine (89%) in 1-pair worms group were higher than those in multi-paired worms group (51% and 65%).
4) Egg distributions in 1-pair worms group were; 60. 7% in liver, 32. 7% in small intestine, 6. 1% in large intestine, and 0.5% in 8 organs (spleen, lungs, pancreas, kidneys, lymph nodes, stomach, brain and testes/ovary).
5) In 6 mice infected each with 1-pair worms, 19%, 21%, 54%, 49%, 64% and 69% of all eggs produced and passed were in the feces; and 81%, 79%, 46%, 51%, 36% and 31% were deposited in tissues in 82, 89, 302, 336, 342 and 394 days after infection respectively.
6) In the tissues, the number of organs affected with eggs were 15 in 1-pair worms group, and 18 in the multi-paired worms group. The extra 3 organs complicated were the heart, esophagus and diaphragm.
7) The dispersal avenue of eggs through the capillary sinusoid of the liver to the general circulation was postulated in view of their distribution in other organs beyond the hepatosystem (Cheever and Warren, 1963), as demonstrated by Pena de Grimaldo and Kershaw (1961).
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