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KMID : 0311219800110010031
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Yonsei Reports on Tropical Medicine
1980 Volume.11 No. 1 p.31 ~ p.38
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Fate of Free-Living Amoebas in Vrious Conditions
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Ahn, Min/安民
Im, Kyung-Il/Yun, Duk-Jin/Soh, Chin-Thack/任敬一/尹德鎭/蘇鎭琸
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Abstract
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Fate of the pathogenic free-living amoebas: Naegleria fowleri and Acanthamoeba culbertsoni, in the outer environment and in mice, an experimental host was studied.
1. The amoebas were detected from the mouse brain tissues in two out of 10 mice inoculated orally. But all the mice inoculated nasally with N. fowleri resulted positive.
2. The amoebas were not detected from contents of the gastrointestin-al tract of mice by oral infection.
3. The amoebas in mucin, pepsin, glucose and trypsin were alive, and propagated, but could not survive in the medium containing hydrochloric acid with pepsin, artificially prepared gastrice juice.
4. The amoebas survived in ordinarilly applicable concentrations of food preservatives up to 75 hours, but were destroyed in 0.5% vinegar in 24 hours.
5. The amoebas survived in sewege water and tap water up to 75 hours.
6. The amoebas tolerated in pesticides, such as Kasugamin, 2,4-D, Bla-s and Hosbel, of practically applicable concentration, except in Diazinon and Cartap.
The above findings prove that N. fowleri and A. culbertsoni can resist to various environmental conditions but are weak to gastric juice which contains acid. It may endorse the reason why the nasal infection predominates the oral infection.
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