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KMID : 0311219890200000120
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Yonsei Reports on Tropical Medicine
1989 Volume.20 No. 0 p.120 ~ p.124
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Biotechnology of Aflatoxins
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Jhee Eun-Chung
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Abstract
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Aflatoxins which is produced by the fungus, asperfillus flavus was widely distributed in the human food supply like cones, peanuts and grains. It has been wellknown to be a potent toxin causing acute aflatoxicosis liver cancer. As informations on aflatoxin problems accumulated, it has become apparent that the risk of exposure to aflatoxins is much less in technologically developed countries than in developing ones. The role of the hepatitis B virus and aflatoxin B, in the developement of primary hepatocellular carcinoma (PHC) was studied in southeast Asia and Africa. Using aflatoxin B, binding to DAN as an indicator of hepatocarcinogenic potency, the effect of antioxidant was examined to see how this agent modulate the hepatocarcino-genesis of aflatoxins in rats. We also find the mechanism of this inhibition by antioxidant is through the modulation of cytosolic detoxifying enzyme, glutathione s-transferases.
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