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KMID : 0338420010160020075
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The Korean Journal of Internal Medicine
2001 Volume.16 No. 2 p.75 ~ p.79
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Survival and Prognostic Factors in Patients with Primary Pulmonary Hypertension
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Kook Jin Chun/Kook Jin Chun
Seong Ho Kim/Byung Jae An/Sang Hyun Kim/Jae Kyung Ha/Taek Jong Hong/Yung Woo Shin
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Abstract
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Objectives: Primary pulmonary hypertension (PPH) that affects predominantly young and productive people is a progressive fatal disease of unknown cause. The objectives of this study were to characterize mortality in patients with PPH and to investigate the factors associated with their survival.
Methods: Thirteen patients with PPH were enrolled between 1988 and 1996 and followed-up through July 1999. Measurements at diagnosis included hemodynamic and pulmonary function variables in addition to information on demographic data and medical history.
Results: 1) The mean age of the patients with PPH enrolled into the study was 36.1 +/- 9.3 years with female predominance. 2) The estimated median survival was 3.4 +/- 0.6 years. 3) Decreased cardiac index was the only significant predictor of mortality (Cox proportional hazards model).
Conclusion: Patients with PPH have a poor survival expectancy. In this limited study with a small number of patients, mortality is largely associated with decreased cardiac index.
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KEYWORD
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Primary pulmonary hypertension, Survival, Prognosis,
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