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KMID : 0338420010160040230
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The Korean Journal of Internal Medicine
2001 Volume.16 No. 4 p.230 ~ p.235
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Expression of Mucosal Cyto-Chemokine mRNAsin Patients with Helicobacter pylori Infection
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Sill Moo Park/Sill Moo Park
Jin Hee Kim/Yo Han Hong/Hye Ryung Jung/Joong Won Park/Jae Gyu Kim/Bung Chul Yoo
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Abstract
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Background: Helicobacter pylori-induced destruction of the gastroduodenal mucosal barrier is initiated with mucosal infiltration of inflammatory cells. Cytokines and chemokines have been suggested to play important roles in the migration and activation of these inflammatory cells into the mucosa. The present study aimed to investigate expression rates of cyto-chemokine mRNAs using gastric mucosal biopsy specimens.
Methods: In 98 patients infected with Helicobacter pylori, mucosal mRNA expression rates of cytokines (IL-1β, IL-6, and IL-10), C-C chemokines (macrophage inflammatory protein 1α [MIP-1α), and macrophage inflammatory protein 10 [MIP-1α], monocyte chemotactic and activating factor (MCAF), regulated on activation, normal T cell expressed and presumably secreted [RANTES] and C-X-C chemokines (IL-8 and growth regulated α [GRO-α]) were examined using reverse transcription polymerase chain reaction (RT-PCR).
Results: The expression rates of mRNA for IL-8, GRO-α, MIP-1α and RANTES were significantly more increased in H. pylori-positive patients than in H. pylori-negative patients. However, the expressions of IL-1β, IL-6 and IL-10 mRNA were statistically not different between two groups. After eradication of H. pylori, expressions of mRNA for three cytokines (IL-1β, IL-6 and IL-10), four C-C chemokines (MIP-1α, MIP-1β, MCAF and RANTES) and two C-X-C chemokines (IL-8 and GRO-α) were significantly decreased.
Conclusion: These results suggest that C-X-C chemokines and some C-C chemokines play important roles in H. pylori-associated peptic ulcer diseases.
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KEYWORD
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Helicobacter pylori, Cytokine, C-C chemokine, C-X-C chemokine,
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