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KMID : 0338420020170010065
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The Korean Journal of Internal Medicine
2002 Volume.17 No. 1 p.65 ~ p.68
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EDTA-dependent Pseudothrombocytopenia Confirmed by Supplementation of Kanamycin ; A Case Report
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Young Il Jo/Hae Lyun Ahn
Young Il Jo/Young Suk Choi/Jung Yeon Lee/Hae Woon Lee/Seong Ryul Kim/Joon Sim/Weon Lee/Chun Jo Jin
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Abstract
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EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the dumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.
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KEYWORD
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Pseudothrombocytopenia, EDTA, Platelet aggregation, Kanamycin,
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