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KMID : 0338420020170010073
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The Korean Journal of Internal Medicine
2002 Volume.17 No. 1 p.73 ~ p.77
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A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
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Sook Hyang Jeong/Seung Seog Ki
Jin Mo Jeong/Seong Ho Kim/Sook Hyang Jeong/Jin Hyuk Lee/Chul Ju Han/You Cheol Kim/Jhin Oh Lee/Young Joon Hong
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Abstract
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5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gastrointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
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KEYWORD
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Fluorouracil, Neuorotoxicity syndromes, Leukoencephalopathy, progressive multifocal,
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