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KMID : 0338420080230010016
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The Korean Journal of Internal Medicine
2008 Volume.23 No. 1 p.16 ~ p.21
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Helicobacter pylori Infection and Peptic Ulcer Disease in Patients with Liver Cirrhosis
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Kim Dong-Joon
Kim Hak-Yang
Kim Sung-Jung
Hahn Tai-Ho
Jang Myung-Kook
Baik Gwang-Ho
Kim Jin-Bong
Park Sang-Hoon
Lee Myung-Seok
Park Choong-Kee
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Abstract
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Background/Aims: We investigated the prevalence and relationship of peptic ulcer disease and Helicobacter pyloriinfection to liver cirrhosis.
Methods : We examined 288 patients with liver cirrhosis, 322 patients with non-ulcer dyspepsia, and 339 patients
with peptic ulcer disease. Rapid urease test and Wright-Giemsa staining were used for diagnosis of H. pylori infection.
Results: The prevalence of peptic ulcer disease in patients with cirrhosis was 24.3%. The prevalence of peptic
ulcer disease in patients with cirrhosis divided into Child-Pugh classes A, B, and C was 22.3%, 21.0%, and 31.3%,
respectively (p>0.05). The prevalence of H. pylori infection in the patients with cirrhosis, non-ulcer dyspepsia, and peptic
ulcer without chronic liver disease were 35.1%, 62.4%, and 73.7%, respectively (p<0.001). The prevalence of H. pylori
infection did not differ depending on whether there was peptic ulcer (35.6%) or not (34.9%) in patients with liver
cirrhosis (p>0.05). The prevalence of H. pylori infection in patients with hepatitis virus-related liver cirrhosis and in the
patients with alcohol-related liver cirrhosis was 42.5% and 22.0%, respectively (p<0.001). The prevalence of H. pylori
infection in patients with Child-Pugh classes A, B, and C liver cirrhosis was 51.5%, 30.5%, and 20.0%, respectively
(p<0.001).
Conclusions :Factors other than H. pylori may be involved in the pathogenesis of peptic ulcer disease in the
setting of liver cirrhosis.
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KEYWORD
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Helicobacter pylori, Liver cirrhosis, Peptic ulcer
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