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KMID : 0338420080230010030
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The Korean Journal of Internal Medicine
2008 Volume.23 No. 1 p.30 ~ p.36
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Epstein-Barr Virus-Positivity in Tumor has no Correlation with the Clinical Outcomes of Patients with Angioimmunoblastic T-cell Lymphoma
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Lee Yun-A
Lee Keun-Wook
Bang Su-Mi
Lee Jong-Seok
Park Byeong-Bae
Kim Won-Seok
Suh Chul-Won
Kang Jung-Hun
Ryoo Baek-Yeol
Lee Jae-Hoon
Shin Dong-Bok
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Abstract
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Background/Aims: Epstein-Barr virus (EBV) is involved in the pathogenesis of angioimmunoblastic T-cell
lymphoma (AILT), but its precise role and prognostic impact are not clear. This study aimed to evaluate the incidence
of EBV-postitivity in the tumor and bone marrow (BM) samples from AILT patients, and their correlations with the
clinical variables and patient survival.
Methods: Seventy AILT cases were identified over a period of 8 years. Twenty seven cases were investigated for
their EBV tumor status, and 10 BM samples of these patients were investigated for their EBV status with using in situ
hybridization (ISH). EBV PCR was performed for the BM mononuclear cells in 8 cases.
Results: Among the 27 tumor specimens, ten (37%) were EBV-positive. Only CD20-negativity in tumor correlated
with the EBV-positivity (p=0.035). In 13 (48%) patients, gross tumor involvement was recognized by hematoxylin-eosin
staining at the time of diagnosis. Among the 10 patients who had additional BM slides available, there were 3 with BM
involvement, and none showed EBV positive results on ISH. EBV PCR of the BM mononuclear cells revealed
one-positive case among 8 patients. This patient was negative for both BM involvement and EBV ISH. The median
overall survival of the 25 treated patients was 48.9 months (95% CI: 18.6～79.2 months). Neither overall survival nor
progression-free survival was related with EBV-positivity of the tumor.
Conclusions : EBV-positivity of tumor had no impact on the prognosis of AILT patients.
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KEYWORD
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Epstein-Barr virus, Angioimmunoblastic T-cell lymphoma, Survival
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