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KMID : 0338420080230020053
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The Korean Journal of Internal Medicine
2008 Volume.23 No. 2 p.53 ~ p.57
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Free T4 is negatively correlated with body mass ndex in euthyroid women
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Sohn Ho-Sang
Jung Eui-Dal
Kim Sung-Hi
Lee Ji-Hyun
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Abstract
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Background/Aims: Overt thyroid dysfunction is well known to affect weight. However, the influence of
normal-range changes in thyroid status on body mass index (BMI) is unclear. We sought to evaluate thyroid function
(free T4, TSH) and its possible relationship with BMI and lipid profiles in euthyroid subjects.
Methods: A total of 1572 euthyroid women (mean age 46.2 years) who visited Daegu Catholic University Medical
Centre for primary health screening participated in this cross-sectional study. Women who were not euthyroid and
women who took thyroid medication were excluded. TSH, free T4, and lipid profile [total-cholesterol, triglyceride (TG),
HDL-C, LDL-C] were evaluated.
Results: Obese euthyroid women had lower free T4 levels than did lean euthyroid women. After adjustment for
age and smoking, free T4, but not TSH, was significantly negatively correlated with BMI. After adjustment for age,
smoking, and BMI, free T4 was negatively correlated with TG to a significant degree.
Conclusions: We demonstrated a negative correlation between free T4 within the normal range and BMI in
euthyroid subjects. These findings suggest that low free T4 is associated with obesity in euthyroid subjects.
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KEYWORD
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Free T4, TSH, Body mass index
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