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KMID : 0338420080230030116
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The Korean Journal of Internal Medicine
2008 Volume.23 No. 3 p.116 ~ p.120
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Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis
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Lee Chang-Youl
Shin Dong-Hwan
Noh Tae-Woong
Chang Yoon-Soo
Kim Hyung-Jung
Ahn Chul-Min
Jeon Jeong-Hee
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Abstract
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Background/Aims: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial.
Methods: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R.
Results: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance.
Conclusions: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
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KEYWORD
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IGF, IGF-1R, Immunohistochemistry, NSCLC
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