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KMID : 0338420090240040362
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The Korean Journal of Internal Medicine
2009 Volume.24 No. 4 p.362 ~ p.367
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Factors for Determining Survival in Acute Organophosphate Poisoning
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Kang Eun-Jung
Seok Su-Jin
Lee Kwon-Hyun
Gil Hyo-Wook
Yang Jong-Oh
Lee Eun-Young
Hong Sae-Yong
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Abstract
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Background/Aims : Organophosphate poisoning has a high mortality rate. Recently, differences among organophosphorus insecticides in human self-poisoning were reported. This study investigated the prognostic risk factors and the mortality of different organophosphates following acute organophosphate poisoning.
Methods: This retrospective study included 68 patients with acute organophosphate poisoning. We investigated patient survival according to initial parameters, including the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum cholinesterase level, and hemoperfusion and evaluated the mortality according to organophosphate types.
Results: Thirteen of the 68 patients died. The agents responsible for mortality were different. The APACHE II score was a significant predictor of mortality (odds ratio [OR], 1.194; p<0.01; 95% confidence interval [CI], 1.089 to 1.309) and respiratory failure (OR, 1.273; p<0.01; 95% CI, 1.122 to 1.444). The mortality was 0% for dichlorvos, malathion, chlorpyrifos and profenofos. However, other organophosphates showed different mortality (16.7% for O-ethyl-O-4-nitrophenyl phenylphosphonothioate, 25% for phenthoate, 37.5% for phosphamidon, 50% for methidathion). The usefulness of hemoperfusion appears to be limited.
Conclusions: The initial APACHE II score is a useful prognostic indicator, and different organophosphates have
different mortality
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KEYWORD
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Organophosphate, Survival, APACHE
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