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KMID : 0338420090240040368
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The Korean Journal of Internal Medicine
2009 Volume.24 No. 4 p.368 ~ p.373
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Elevation of Serum Ferritin is Associated with the Outcome of Patients with Newly Diagnosed Multiple Myeloma
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Song Moo-Kon
Shin Ho-Jin
Choi Young-Jin
Cho Goon-Jae
Chung Joo-Seop
Seol Young-Mi
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Abstract
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Background/Aims : Serum ferritin is a marker of acute phase reactions and iron storage. In addition, hematologic malignancies are associated with elevated serum ferritin levels. Other studies have suggested that ferritin is a surrogate for advanced disease and has an impact on relapse, because elevated serum ferritin predicts overall survival (OS) and relapse-free survival following autologous stem cell transplantation for lymphomas.
Methods: We studied 89 consecutive patients with newly diagnosed multiple myeloma to determine the value of serum ferritin in comparison with known prognostic factors.
Results: The OS in the elevated serum ferritin group (≥300 ng/mL) was shorter than that in the normal serum ferritin group (<300 ng/mL, p<0.001) after a median follow-up of 25 months. In univariate analysis, elevated ferritin was correlated with poor survival in the patients (relative risk [RR], 2.588; 95% confidence interval [CI], 1.536 to 4.358; p<0.001). Furthermore, multivariate analysis showed that elevated serum ferritin was an independent predictor of mortality in patients with multiple myeloma (RR, 2.594; 95% CI, 1.403 to 4.797; p=0.002).
Conclusions: The serum ferritin can a prognostic parameter of survival as well as disease activity in patients with multiple myeloma.
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KEYWORD
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Ferritin, Multiple myeloma, Survival
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