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KMID : 0338420100250010044
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The Korean Journal of Internal Medicine
2010 Volume.25 No. 1 p.44 ~ p.50
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Relation of Anti- to Pro-Inflammatory Cytokine Ratios with Acute Myocardial Infarction
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Santanu Biswas
Nripendranath Mandal
Pradip K. Ghoshal
Sankar C. Mandal
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Abstract
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Background/Aims : Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate the association between anti-inflammatory and pro-inflammatory cytokines ratios and AMI.
Methods: A total of 90 AMI patients and 90 age-and sex-matched controls were recruited in this study. Plasma cytokines and conventional risk factors were determined by standard methods.
Results: Patients with AMI showed increased interleukin (IL)-6 and tumor necrosis factor-α levels and lower anti- to pro-inflammatory cytokine ratios as compared with controls. A multivariate logistic regression analysis revealed that IL-10 to IL-6 ratio was independently associated with the occurrence of AMI (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.39 to 12.17; p < 0.0001). In contrast, IL-6 levels were no longer significant in the multivariate model (OR, 1.02; 95% CI, 0.932 to 1.12; p = 0.603). A receiver operating characteristic (ROC) curve analysis indicated that IL-6 levels and IL-10 to IL-6 ratios were a significant predictor of AMI (area under ROC curve, 0.892 and 0.851, respectively).
Conclusions: Our results suggest that the ratio of IL-10 to IL-6 is independently associated with AMI, and reduced levels of this ratio may favor the development of AMI.
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KEYWORD
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Myocardial infarction, acute, Cytokines, inflammatory, ROC curve
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