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KMID : 0338420100250010110
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The Korean Journal of Internal Medicine
2010 Volume.25 No. 1 p.110 ~ p.113
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A Case Report of the Second de Novo Acute Myeloid Leukemia (AML) Following Allogeneic Stem Cell Transplantation in a Patient with the First AML
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Cho Byung-Sik
Kim Hee-Je
Eom Ki-Sung
Lee Jong-Wook
Min Woo-Sung
Kim Chun-Choo
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Abstract
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Secondary leukemia occurring after hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia (AML) is rare. Secondary AML usually follows autologous and not allogeneic transplants. When a new leukemia develops in a patient successfully treated with an allogeneic HSCT, the possibility of a de novo or secondary leukemia from either the donor or recipient should be considered. We present a case initially diagnosed as de novo AML without a cytogenetic abnormality. The patient was successfully treated with an HLA-matched sibling allogeneic HSCT. However, more than six years later, AML developed again and was associated with new complex cytogenetic abnormalities. After a second HSCT, the patient has been followed without serious complications. Considering the allogeneic setting, the newly developed cytogenetic abnormalities, a relatively long latent period, and the good clinical course after the second allogeneic HSCT, this case might represent a second de novo AML following successful treatment of the first AML.
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KEYWORD
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Leukemia, myeloid, acute, Hematopoietic stem cell transplantation
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