|
KMID : 0338420100250020213
|
|
The Korean Journal of Internal Medicine
2010 Volume.25 No. 2 p.213 ~ p.216
|
|
|
Two Lung Masses with Different Responses to Pemetrexed
|
|
Park Kwang-Young
Jeong Jae-Wook
Nam Seung-Bum
Lee Ho-Jin
Kim Hyo-Seok
Choi Yoon-Hee
Lee Jae-Cheol
|
|
|
Abstract
|
|
|
|
We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs.
|
|
|
KEYWORD
|
|
|
Lung neoplasms, Pemetrexed, Neoplasms, multiple primary, Drug resistance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|