|
KMID : 0338420110260010034
|
|
The Korean Journal of Internal Medicine
2011 Volume.26 No. 1 p.34 ~ p.40
|
|
|
Prognostic Factors Associated with Survival in Patients with Primary Duodenal Adenocarcinoma
|
|
Chung Woo-Chul
Paik Chang-Nyol
Jung Sung-Hoon
Lee Kang-Moon
Kim Sang-Woo
Chang U-Im
Yang Jin-Mo
|
|
|
Abstract
|
|
|
Background/Aims: The prognostic factors in primary duodenal adenocarcinoma remain controversial. This study
evaluated the prognostic factors associated with survival in patients with primary duodenal adenocarcinoma.
Methods: From March 1996 to June 2008, the medical records of 30 patients with a final diagnosis of primary
duodenal epithelial malignancy seen at two referral centers were reviewed retrospectively. The prognostic factors for survival were evaluated 6 months and 1, 2, and 5 years after the diagnosis.
Results: The median survival was 5.7 months. The survival rate was 46.7% (14/30), 16.7% (5/30), 10% (3/30),
and 6.7% (2/30) at 6 months and 1, 2, and 5 years, respectively. Multivariate analysis showed that cancer-directed
treatment, including curative surgery or chemotherapy, was a common independent risk factor at all follow-up times. Total bilirubin, cytology, and TNM stage were independent risk factors for survival at 1, 2, and 5 years. The white blood cell count was an independent risk factor at 1 year only. The actuarial probability of survival in patients undergoing cancer-directed treatment was significantly higher than in those without treatment at 6 months (71.4 vs. 25.0%, p < 0.01), 1 year (28.6 vs. 6.3%, p < 0.01), 2 years (21.4 vs. 0%, p < 0.01), and 5 years (14.3 vs. 0%, p < 0.01).
Conclusions: The prognostic factors in patients with primary duodenal adenocarcinoma were total bilirubin, TNM stage, cytology, and cancer-directed treatments until the 5-year follow-up. Especially, cancer-directed treatments improved patient survival.
|
|
|
KEYWORD
|
|
|
Duodenal cacner, Prognosis, Cancer-directed treatment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|