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KMID : 0338420110260010041
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The Korean Journal of Internal Medicine
2011 Volume.26 No. 1 p.41 ~ p.46
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Two-Year Clinical Outcome after Carvedilol-Loaded Stent Implantation in Patients with Coronary Artery Disease
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Kim Hyun-Kuk
Hong Young-Joon
Jeong Myung-Ho
Kim Weon
Kim Sung-Soo
Ko Jum-Suk
Lee Min-Goo
Sim Doo-Sun
Park Keun-Ho
Yoon Nam-Sik
Yoon Hyun-Ju
Kim Kye-Hun
Park Hyung-Wook
Kim Ju-Han
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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Background/Aims: Carvedilol is an antioxidant that inhibits smooth muscle cell proliferation and migration. The
aim of this study was to investigate the beneficial effects of carvedilol-loaded stents on 2-year clinical outcomes
after stent implantation in patients with coronary artery disease.
Methods: We performed a prospective trial with male subjects to compare the safety and effects of carvedilolloaded BiodivYsio® stents implanted into 20 patients with those of bare-metal BiodivYsio® stents implanted into
21 patients for de novo coronary lesions. The primary end point was the degree of neointimal hyperplasia, which was measured by intravascular ultrasound (IVUS) 6 months after the procedure; the secondary end point was major adverse cardiac events (MACE) at 2 years after implantation. All carvedilol and control stents were deployed successfully.
Results: A 2-year follow-up was completed for 19 patients (95%) in the carvedilol stent group and 20 patients
(95%) in the control stent group. IVUS showed a trend toward a larger luminal area (6.86 ± 2.59 vs. 5.47 ± 1.52mm2, p = 0.267), smaller neointimal area (1.34 ± 0.70 vs. 2.40 ± 1.73 mm2, p = 0.18), and reduced net decrease in luminal area (-0.78 ± 0.97 vs. -1.89 ± 1.78 mm2, p = 0.106) in the carvedilol stent group compared with the control stent group, respectively. There were no significant differences in the incidence of MACE (10.5 vs. 30.0%, respectively, p = 0.132) between the groups at 2 years after stent implantation. Stent thrombosis did not occur in either group after 2 years.
Conclusions: The carvedilol-loaded stents tended to inhibit neointimal hyperplasia without the occurrence of
cardiac death, myocardial infarction, or stent thrombosis at 2-year follow-up.
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KEYWORD
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Coronary artery disease, Antioxidants, Stents
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