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KMID : 0338420110260010047
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The Korean Journal of Internal Medicine
2011 Volume.26 No. 1 p.47 ~ p.53
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Effects of the Transition from Premenopause to Postmenopause on Lipids and Lipoproteins: Quantification and Related Parameters
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Cho Eun-Jeung
Min Yun-Joo
Oh Min-Seok
Kwon Jee-Eun
Kim Jeung-Eun
Lee Wang-Soo
Lee Kwang-Je
Kim Sang-Wook
Kim Tae-Ho
Kim Myung-A
Kim Chee-Jeong
Ryu Wang-Seong
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Abstract
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Background/Aims: The aim of this study was to quantitatively measure changes in lipids and lipoproteins during
perimenopause and to identify variables related to these changes.
Methods: Among women who had three regular health evaluations over a span of 2-4 years, 34 women remained
in the premenopausal state, 34 premenopausal women transitioned to the postmenopausal state, and 36 postmenopausal
women were enrolled. The menopausal state was determined not only by a history of amenorrhea but also by levels of female sex hormones. Yearly changes in lipids were calculated using a linear regression of the three measurements.
Results: The transition from premenopause to postmenopause was associated with increased total cholesterol
and low-density lipoprotein (LDL) cholesterol levels by 7.4 ± 8.0 mg/dL (4.2 ± 4.9%) and 6.9 ± 6.5 mg/dL (6.8 ± 7.0
%) over one year, resulting in an elevation of 19.6 ± 22.6 mg/dL (10.9 ± 13.0%) and 18.9 ± 19.5 mg/dL (18.6 ± 20.3%), respectively, during perimenopause. There were no changes observed in premenopausal and postmenopausal women. Body weight, blood pressure, high-density lipoprotein (HDL) cholesterol, and triglycerides did not change in any of the three groups. In all women, changes in both total cholesterol and LDL cholesterol were associated with changes in follicle stimulating hormone (r = 0.40, p < 0.001 and r = 0.38, p < 0.001, respectively). Changes in triglycerides were associated with changes in body weight (r = 0.28, p = 0.005).
Conclusions: During perimenopause, total and LDL cholesterol levels increase and these changes in cholesterol
are mainly dependent on changes in female sex hormones.
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KEYWORD
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Lipids, Lipoproteins, Menopause, Gonadal steroid hormones
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