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KMID : 0338420110260020153
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The Korean Journal of Internal Medicine
2011 Volume.26 No. 2 p.153 ~ p.159
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Retrospective Comparison of Levofloxacin and Moxifloxacin on Multidrug-Resistant Tuberculosis Treatment Outcomes
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Lee Jin-Woo
Lee Chang-Hoon
Kim Deog-Kyeom
Yoon Ho-Il
Kim Jae-Yeol
Lee Sang-Min
Yang Seok-Chul
Lee Jae-Ho
Yoo Chul-Gyu
Lee Choon-Taek
Chung Hee-Soon
Kim Young-Whan
Han Sung-Koo
Yim Jae-Joon
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Abstract
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Background/Aims: To compare the effect of levofloxacin and moxifloxacin on treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB).
Methods: A retrospective analysis of 171 patients with MDR-TB receiving either levofloxacin or moxifloxacin was performed. Treatment responses were categorized into treatment success (cured and treatment completed) or adverse treatment outcome (death, failure, and relapsed).
Results: The median age of the patients was 42.0 years. Approximately 56% of the patients were male. Seventeen patients had extensively drug-resistant tuberculosis, and 20 had a surgical resection. A total of 123 patients (71.9%) received levofloxacin for a median 594 days, and 48 patients (28.1%) received moxifloxacin for a median 673 days. Other baseline demographic, clinical, and radiographic characteristics were similar between the two groups. The moxifloxacin group had a significantly higher number of resistant drugs (p < 0.001) and a higher incidence of resistance to ofloxacin (p = 0.005) in the drug sensitivity test. The treatment success rate was 78.9% in the levofloxacin group and 83.3% in the moxifloxacin group (p = 0.42). Adverse reactions occurred at similar rates in the groups (p = 0.44). Patients in the moxifloxacin group were not more likely to have treatment success than those in the levofloxacin group (adjusted odds ratio, 0.76; 95% confidence interval, 0.24 to 2.43; p = 0.65).
Conclusions: Both levofloxacin and moxifloxacin showed equivalent efficacy for treating MDR-TB.
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KEYWORD
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Levofloxacin, Moxifloxacin, Tuberculosis, multidrug-resistant, Quinolones, Tuberculosis
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