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KMID : 0338420110260020187
The Korean Journal of Internal Medicine
2011 Volume.26 No. 2 p.187 ~ p.194
Role of IL-1¥á in Cisplatin-Induced Acute Renal Failure in Mice
Lee Jay-Wook

Nam Woo-Jin
Han Min-Jee
Shin Jung-Ho
Kim Jin-Gun
Kim Su-Hyun
Kim Hye-Ryoun
Oh Dong-Jin
Abstract
Background/Aims: For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1¥á. We thus asked whether IL-1¥á deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice.

Methods: Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1¥á was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1¥á -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1¥á -/- mice.

Results: Compared with vehicle-treated mice, renal IL-1¥á increased in cisplatin-treated wild-type mice beginning on day 1. IL-1¥á -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL?1¥á -/- mice.

Conclusions: Mice deficient in IL-1¥á are protected against cisplatin-induced ARF. The lack of IL-1¥á may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1¥á -/- mice in cisplatin-induced ARF merits further study.
KEYWORD
Cisplatin, Interleukin-1alpha, Acute kidney injury
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