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KMID : 0338420110260030285
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The Korean Journal of Internal Medicine
2011 Volume.26 No. 3 p.285 ~ p.293
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Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women
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Kim Sang-Soo
Lee Jeong-Gyu
Kim Dong-Wok
Kim Bo-Hyun
Jeon Young-Jae
Kim Mi-Ra
Huh Jeong-Eun
Mok Ji-Young
Kim Seong-Jang
Kim In-Ju
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Abstract
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Background/Aims: The objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status.
Methods: The study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status.
Results: Analysis of premenopausal women showed no significant differences in the homeostasis model of assessmentinsulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.
Conclusions: Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.
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KEYWORD
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Gallstones, Insulin resistance, Metabolic syndrome, Postmenopause
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