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KMID : 0338420110260040427
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The Korean Journal of Internal Medicine
2011 Volume.26 No. 4 p.427 ~ p.431
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Gender Differences in Susceptibility to Smoking among Patients with Lung Cancer
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Ryu Jeong-Seon
Jeon Sang-Hoon
Kim Jung-Soo
Lee Jung-Hwan
Kim Seong-Hyun
Hong Ji-Taek
Jeong Ju-Hong
Jeong Ji-Joong
Lee Myung-Dong
Min Sang-Joon
Nam Hae-Seong
Cho Jae-Hwa
Kwak Seung-Min
Lee Hong-Lyeol
Kim Hyun-Jung
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Abstract
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Background/Aims: To determine whether female smokers are more or less susceptible to the detrimental pulmonaryfunction effects of smoking when compared to male smokers among patients with lung cancer.
Methods: Pack-years and pulmonary function indices were compared between 1,594 men and women with lung cancer who were smokers or had a history of smoking. Differences in individual susceptibility to smoking were estimated using a susceptibility index formula.
Results: Of the patients, 959 (92.8%) men and 74 (7.2%) women were current smokers. Common histological types of lung cancer were squamous cell carcinoma, adenocarcinoma, and small cell carcinoma, among others. Women had a lower number of pack-years, forced expiratory volume in 1 second (FEV1, liters), forced vital capacity (FVC, liters), and total lung capacity (TLC, liters) compared to those of men (25.0 ± 19.2 vs. 42.9 ± 21.7 for pack-years; 1.4 ± 0.5 vs. 2.0 ± 0.6 for FEV1; 3.0 ± 0.7 vs. 2.0 ± 0.6 for FVC; 4.5 ± 0.8 vs. 5.7 ± 1.0 for TLC; all p < 0.001). The susceptibility index for women was significantly higher compared to that of men (1.1 ± 4.1 vs. 0.7 ± 1.1; p = 0.001). A significant inverse association was shown between the susceptibility index and TLC and FVC (r = -0.200 for TLC, -0.273 for FVC; all p < 0.001).
Conclusions: The results suggest that the detrimental effects of smoking on pulmonary function are greater in women, as compared to those in men, among patients with lung cancer.
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KEYWORD
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Gender, Lung neoplasms, Smoking, Disease susceptibility, Pulmonary function
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