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KMID : 0338420110260040463
The Korean Journal of Internal Medicine
2011 Volume.26 No. 4 p.463 ~ p.465
Acute Kidney Injury due to Sodium Bromate Intoxication: A Report of Two Cases
Ryu Dong-Hwan

Jang Kyung-Ae
Kim Seok-Min
Park Jong-Won
Do Jun-Young
Yoon Kyung-Woo
Abstract
Sodium bromate is a strong oxidant used as a neutralizing solution in hair permanents, as well as an auxiliary agent in printing and dyeing. Accidental or deliberate ingestion of bromate solution has rarely been reported in Korea. The clinical manifestations of bromate intoxication are vomiting, diarrhea, central nervous system symptoms, oliguric or non-oliguric acute kidney injury, hemolytic anemia, and deafness; most of these manifestations are reversible, with the exception of renal failure and deafness. Here, we report on two patients who demonstrated distinct clinical progressions. In the first case, a 16-year-old woman was successfully treated with hemodialysis and recovered renal function without hearing loss. However, in the second case, delayed hemodialysis resulted in persistent renal failure and hearing loss in a 77-yearold woman. This suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, as the rapid removal of bromate may be essential to preventing severe intoxication and its sequelae.
KEYWORD
Acute kidney injury, Sodium bromate
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