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KMID : 0338420120270010066
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The Korean Journal of Internal Medicine
2012 Volume.27 No. 1 p.66 ~ p.71
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Associations among Body Mass Index, Insulin Resistance, and Pancreatic ß-Cell Function in Korean Patients with New- Onset Type 2 Diabetes
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Chung Jin-Ook
Cho Dong-Hyeok
Chung Dong-Jin
Chung Min-Young
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Abstract
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Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and β-cell function in Korean patients newly presenting with type 2 diabetes.
Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated.
Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMAIR), homeostasis model assessment of β-cell function (HOMA-β), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-β and inverse associations with the DI.
Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with β-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
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KEYWORD
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Body mass index, Insulin resistance, Secretion, Diabetes mellitus, type 2
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