KMID : 0338420120270030293
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The Korean Journal of Internal Medicine 2012 Volume.27 No. 3 p.293 ~ p.300
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Validation of the Oxford Classification of IgA Nephropathy: A Single-Center Study in Korean Adults
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Lee Ho-Young
Yi Sul-Hee Seo Mi-Seon Hyun Jin-Nam Jeon Jin-Seok Noh Hyun-Jin Han Dong-Cheol Hwang Seung-Duk Jin So-Young Kwon Soon-Hyo
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Abstract
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Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population.
Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at
Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee¡¯s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly.
Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ¡¾ 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan?Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions.
Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.
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KEYWORD
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Histology, Prognosis, Glomerulonephritis, IgA
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