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KMID : 0338420130280040449
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The Korean Journal of Internal Medicine
2013 Volume.28 No. 4 p.449 ~ p.455
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The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer
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Lee Kyoung-Ju
Lee Eun-Joo
Hur Gyu-Young
Lee Sang-Yeub
Kim Je-Hyeong
Shin Chol
Shim Jae-Jeong
In Kwang-Ho
Kang Kyung-Ho
Yoo Se-Hwa
Lee Sung-Yong
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Abstract
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Background/Aims: Chemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal chemotherapy and radiation schedule for LS-SCLC remains controversial. Therefore we analyzed the time from the start of any treatment until the end of radiotherapy (SER) in patients with LS-SCLC.
Methods: We retrospectively analyzed 29 patients diagnosed histologically with LS-SCLC and divided them into two groups: a short SER group (< 60 days) and a long SER (> 60 days) group. Patients were treated with irinotecan-based chemotherapy and thoracic radiotherapy.
Results: Sixteen patients were in the short SER group and 13 patients were in the long SER group. Short SER significantly prolonged survival rate (p = 0.03) compared with that of long SER. However, no significant differences in side effects were observed.
Conclusions: Short SER should be considered to improve the outcome of concurrent chemoradiotherapy for LS-SCLC.
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KEYWORD
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Small cell lung carcinoma, Limited-stage, Chemoradiotherapy, Start of any treatment until the end of radiotherapy
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