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KMID : 0338420130280050579
The Korean Journal of Internal Medicine
2013 Volume.28 No. 5 p.579 ~ p.586
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
Jin Heung-Yong

Cha Youn-Soo
Baek Hong-Sun
Park Tae-Sun
Abstract
Background/Aims: Vitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD).

Methods: Mice were divided into four groups according to VVE dose: those fed a normal diet (ND; n = 10), HD (n = 10), HD with 100 mg/kg VVE (n = 10), and HD with 250 mg/kg VVE (n = 10). After 12 weeks, immunohistochemical analyses were carried out using a polyclonal antibody against antiprotein gene product 9.5 (protein-gene-product, 9.5), and intraepidermal innervation was subsequently quantified as nerve fiber abundance per unit length of epidermis (intraepidermal nerve fiber, IENF/mm).

Results: Daily administration of VVE at doses of 100 or 250 mg/kg for 12 weeks protected HD mice from nerve fiber loss compared to untreated mice, as follows (IENF/mm): controls (40.95 ¡¾ 5.40), HD (28.70 ¡¾ 6.37), HD with 100 mg/kg (41.14 ¡¾ 1.12), and HD with 250 mg/kg (48.98 ¡¾ 7.01; p < 0.05, HD with VVE vs. HD).

Conclusions: This study provides scientific support for the therapeutic potential of VVE in peripheral neuropathy in an HD mouse model. Our results suggest that VVE could play a role in the management of peripheral neuropathy, similar to other antioxidants known to be beneficial for diabetic peripheral neuropathy.
KEYWORD
Antioxidants, Diet, high-fat, Peripheral nervous system diseases, Prediabetic state, Vitis vinifera grape seed extract
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