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KMID : 0338420130280050609
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The Korean Journal of Internal Medicine
2013 Volume.28 No. 5 p.609 ~ p.613
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Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype
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Han Dong-Hee
Moh In-Ho
Kim Doo-Man
Ihm Sung-Hee
Choi Moon-Gi
Yoo Hyung-Joon
Hong Eun-Gyoung
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Abstract
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We report the case of a patient who experienced extreme recurrent gestational hyperlipidemia. She was diagnosed with partial lipoprotein lipase (LPL) deficiency but without an associated LPL gene mutation in the presence of the apolipoprotein E3/2 genotype. This is the first reported case of extreme gestational hyperlipidemia with a partial LPL deficiency in the absence of an LPL gene mutation and the apolipoprotein E 3/2 genotype. She was managed with strict dietary control and medicated with omega-3 acid ethyl esters. A patient with extreme hyperlipidemia that is limited to the gestational period should be considered partially LPL-deficient. Extreme instances of hyperlipidemia increase the risk of acute pancreatitis, and the effect of parturition on declining plasma lipid levels can be immediate and dramatic. Therefore, decisions regarding the timing and route of delivery with extreme gestational hyperlipidemia are critical and should be made carefully.
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KEYWORD
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Apolipoproteins E, Hyperlipidemias, Lipoprotein lipase, Pregnancy
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