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KMID : 0338420140290010031
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The Korean Journal of Internal Medicine
2014 Volume.29 No. 1 p.31 ~ p.39
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Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome
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Kim Jung-Hee
Baik Hyun-Wook
Yoon Yeong-Sook
Joung Hyo-Jee
Park Ju-Sang
Park Sang-Jong
Jang Eun-Jeong
Park Sang-Woon
Kim Sang-Jung
Kim Mi-Jeoung
Jeon Dong-Ok
Cho Hyo-Jin
Lee Sang-Jin
Im Sung-Gyu
Jang Sun-Kyung
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Abstract
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Background/Aims: Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors.
Methods: We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 ± 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 ± 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed.
Results: The mean BAP of the MetS group (1,937.3 ± 36.5 μmol/L) was significantly lower than that of the non-MetS group (2,101.7 ± 29.5 μmol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively.
Conclusions: Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.
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KEYWORD
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Metabolic syndrome, Oxidative stress, Adiponectin, Insulin
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