|
KMID : 0338420140290020246
|
|
The Korean Journal of Internal Medicine
2014 Volume.29 No. 2 p.246 ~ p.249
|
|
|
Ifosfamide-induced Fanconi syndrome with diabetes insipidus
|
|
Leem Ah-Young
Kim Han-Sang
Yoo Byung-Woo
Kang Beo-Deul
Kim Min-Hwan
Rha Sun-Young
Kim Hyo-Song
|
|
|
Abstract
|
|
|
|
Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40?60 g/m2, a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied by type II proximal renal tubular dysfunction, as evidenced by glycosuria, proteinuria, electrolyte loss, and metabolic acidosis. Diabetes insipidus is also a rare complication of ifosfamide-induced renal disease. We herein describe a case involving a 61-year-old man who developed ifosfamide-induced Fanconi syndrome accompanied by diabetes insipidus only a few days after the first round of chemotherapy. He had no known risk factors. In addition, we briefly review the mechanisms and possible therapeutic options for this condition based on other cases in the literature. Patients who receive ifosfamide must be closely monitored for renal impairment to avoid this rare but fatal complication.
|
|
|
KEYWORD
|
|
|
Ifosfamide, Fanconi syndrome, Diabetes insipidus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|