|
KMID : 0338420140290030334
|
|
The Korean Journal of Internal Medicine
2014 Volume.29 No. 3 p.334 ~ p.340
|
|
|
Urinary excretion of β2-microglobulin as a prognostic marker in immunoglobulin A nephropathy
|
|
Shin Jae-Ryung
Kim Seung-Min
Yoo Jung-Sun
Park Ji-Yoon
Kim Seul-Ki
Cho Joo-Hee
Jeong Kyung-Hwan
Lee Tae-Won
Ihm Chun-Gyoo
|
|
|
Abstract
|
|
|
Background/Aims: β2-microglobulin (β2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary β2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a biomarker of immunoglobulin A nephropathy (IgAN) is unclear.
Methods: We included urinary β2-MG levels in the routine laboratory examination of all inpatients with biopsy-proven IgAN at our hospital from 2006 to 2010. We retrospectively analyzed the correlation between β2-MG levels and clinical parameters as a prognostic biomarker of IgAN.
Results: A total of 51 patients (30 males, 21 females; mean age, 33.01 ± 12.73 years) with IgAN were included in this study. Initial demographic, clinical, and laboratory data for all patients are listed. The mean initial estimated glomerular filtration rate and 24-hour urine protein levels were 94.69 ± 34.78 mL/min/1.73 m2 and 1.28 ± 1.75 g/day, respectively. The mean level of urinary β2-MG was 1.92 ± 7.38 μg/ mg creatinine. There was a significant correlation between initial serum creatinine (iSCr), urine protein creatinine ratio (UPCR), and the level of β2-MG (r = 0.744, r = 0.667, p < 0.01). There was also a significant correlation between renal function tests and the level of urinary β2-MG (p < 0.01). Cox regression analysis showed that albumin, β2-MG, iSCr, and UPCR were significant predictors of disease progression in IgAN.
Conclusions: Urinary β2-MG levels showed a significant correlation with renal function and proteinuria in IgAN. Thus, we propose that urinary β2-MG may be an additional prognostic factor in patients with IgAN.
|
|
|
KEYWORD
|
|
|
Urinary β2-microglobulin, Glomerulonephritis, IGA, Prognostic factor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|