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KMID : 0338420140290030341
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The Korean Journal of Internal Medicine
2014 Volume.29 No. 3 p.341 ~ p.351
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A mild decrease of renal function is related to increased hemoglobin level during 5-year follow-up period
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Shin Na-Ra
Kim Hyun-Suk
Kim Hyo-Jin
Han Mi-Yeun
Lee Sun-Hwa
Jo Hyung-Ah
Huh Hyuk
Chin Ho-Jun
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Abstract
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Background/Aims: We analyzed chronological changes in hemoglobin according to renal function changes over a 5-year follow-up period.
Methods: We enrolled 5,266 adults with a glomerular filtration rate (GFR) ≥ 60 mL/min/1.73 m2 at an initial examination at a routine health check-up; a follow- up examination was conducted 5 years later. We categorized the subjects according to GFR ratio (groups 1, 2, and 3, defined as GFRratio ≥ 1.00, 0.75 to 0.99, and < 0.75, respectively).
Results: The mean hemoglobin level in subjects with a GFR of 60 to 74 was higher than in those with a GFR of 75 to 89 or ≥ 90 mL/min/1.73 m2 at the initial examination (all p < 0.001). Among females and males, the frequencies of increased hemoglobin were 46.8% and 40.6% in the GFRratio group 1, 52.4% and 46.1% in group 2, and 59.6% and 52.5% in group 3 over the 5-year period, respectively (all p < 0.001). With multiple logistic regression, group 3 showed 1.594-fold (95% confidence interval [CI], 1.127 to 2.225) and 1.353-fold (95% CI, 1.000 to 1.830) higher likelihoods of increased hemoglobin over the 5-year follow-up period in females and males, respectively. The estimated difference in hemoglobin level was highest in group 3 in both genders. These findings were more evident in subgroups without metabolic syndrome, diabetes mellitus, hypertension, or GFR less than 90 mL/min/1.73 m2.
Conclusions: Among a population with GFR ≥ 60 mL/min/1.73 m2, a mild decrease in GFR over a 5-year follow-up period was associated with an increase in hemoglobin levels.
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KEYWORD
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Chronic kidney failure, Hemoglobins, Erythropoiesis
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