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KMID : 0338420140290030352
The Korean Journal of Internal Medicine
2014 Volume.29 No. 3 p.352 ~ p.360
Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer¡¯s ring: nationwide Korean study
Lee Seong-Jun

Suh Cheol-Won
Lee Soon-Il
Kim Won-Seog
Lee Won-Sik
Kim Hyo-Jung
Choi Chul-Won
Kim Jin-Seok
Shin Ho-Jin
Abstract
Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer¡¯s ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively.

Methods: From January 2000 through December 2010, we analyzed the medical records of 328 patients from nine Korean institutions who were diagnosed with WR-NHL.

Results: The study group comprised 197 male and 131 female patients with a median age of 58 years (range, 14 to 89). The rate of localized disease (stage I/II) was 64.9%, and that of low-risk disease (low/low-intermediate, as defined by the International Prognostic Index) was 76.8%. Diffuse large B-cell lymphoma (DLBCL; 240 patients, 73.2%) was the most common pathologic subtype, followed by peripheral T-cell lymphoma (14 patients, 4.3%) and nasal NK/T-cell lymphoma (14 patients, 4.3%). WR-NHL occurred most frequently in the tonsils (199 patients, 60.6%). Extranodal involvement was greater with the T-cell subtype (20 patients, 42.5%) compared with the B-cell subtype (69 patients, 24.5%). Multivariate analyses showed that age ¡Ã 62 years, T-cell subtype, and failure to achieve complete remission were significant risk factors for overall survival.

Conclusions: DLBCL was found to have a higher incidence in Korea than those incidences reported by other WR-NHL studies. T-cell lymphoma occurred more frequently than did follicular lymphoma. T-cell subtype, age ¡Ã 62 years, and complete remission failure after first-line treatment were significant poor prognostic factors for overall survival according to the multivariate analysis.
KEYWORD
Head and neck, Non-Hodgkin lymphoma, Diffuse large B-cell lymphoma, T-cell lymphoma
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